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GSH also neutralizes oxidative stress mediated by pyocyanin likely through oxidant-scavenging and rebalancing of the cellular redox status

In turn, glutathione might increase recycling of vitamin C, enhancing its protective effect on oxidative stress (5)

Furthermore, providing more acetyl-groups by treatment with an acetyl-donor can increase histone acetylation levels (Bergamasco et al, 2024)

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However, glutathione doesn't absorb well into the skin, and it's easy to conflict with other topical skin treatments you want to use, so it's generally not recommended for systemic use