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158(7):23092318 Sun GW, Kobayashi H, Suzuki M, Kanayama N, Terao T (2003) Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells

Never discontinue prescribed medications in favour of supplements without medical supervision

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It depends on how severe the deficiency is, the dose, and how the body responds