Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
Anaphylactic shock and death have been reported after parenteral vitamin B 12 administration
For patients who could achieve the same results with oral supplementation, the cost difference is substantial and worth discussing with your provider
The more compelling reason for B12 inclusion involves its potential to reduce one of the most common and most disruptive side effects of GLP-1 therapy
Dosage and frequency of administration will depend on the individual's condition, severity of deficiency, and response to treatment