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In conclusion, treatment with EGCG at high doses or for prolonged duration may have adverse effects, and the above data suggest that the boundary between protective and toxic doses of EGCG may be narrow
(2011) and Hazzaa et al
Transcription fator NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
As shown in Figure 3A, reduced expression levels of IL-6 and 8 and MMP3, 12 and 13 were observed in the FOXO4-DRI treated group, which however were concomitantly accompanied with reduced expression of SOX9 and COL2 , as well as increased expression of CDKN2A, CDKN1A , and TP53 (encoding p53)
For instance, the introduction of once-weekly injections has improved adherence rates, with studies showing anotable increase in patient compliance compared to daily regimens
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