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Obesity 23:S1S26 Magkos F, Fraterrigo G, Yoshino J et al (2016) Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity

An initial demyelinating event occurs when a wave of autoreactive immune cells breach the BBB and create areas of intense inflammation that strip myelin off axons, known as demyelination, and injure myelin-producing cells, known as oligodendrocytes

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dose adjustment may be necessary