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A separate principal component analysis testing for sex-driven variability among the study participants revealed significant differences between female and male subjects within the healthy but not in the APP group (Supplementary Fig

2012;97(8):273240 Shishehbor MH, Oliveira LP, Lauer MS, Sprecher DL, Wolski K, Cho L,

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McCarthy MM, Wright CL

In addition, when administered orally, the LD50 value of shikonin is greater than 1 g/kg, indicating relatively low toxicity