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SURPASS-CVOT (tirzepatide): Ongoing trial expected to demonstrate cardiovascular benefits

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In vitro experiments showed that 10 ng/mL IGF-1 LR3 could increase the proliferation rate of breast cancer MCF-7 cells by three times, and reduce the sensitivity of chemotherapy drugs (such as paclitaxel) by 40%

FOXO4-DRI inhibited SLE BM-MSC survival and induced apoptosis (normal cell death) more than 2 fold, suggesting that FOXO4-DRI can induce apoptosis of senescent SLE BM-MSCs

PLOS ONE (2015)