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An imbalance in the microbiome is now recognized as a significant factor contributing to depression

Pancreatic cell-derived glucagon-related peptides are required for cell adaptation and glucose homeostasis

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On the other hand, under specific pathophysiological conditions (e.g., low-dose exposure or acute stress), TMAO activates endoplasmic reticulum (ER) stress-protective pathways or upregulates antioxidant enzyme expression, demonstrating a potential compensatory effect on myocardial tissue

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