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Akhter Hossain at the University of Melbourne in Australia has suggested rather than adding a fatty acid side chain, a glycan group may work instead which is more hydrophilic and therefore easier to dissolve and purify
Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH, et al
Do I need to change my levothyroxine dose if I start a GLP-1
Regrettably, people with type 1 diabetes have not been able to benefit from this expanded armamentarium of therapeutic agents and remain at unacceptably high risk of kidney and cardiovascular complications
In comparison to small molecule drugs, peptides possess greater specificity and fewer off-target effects but typically degrade faster
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