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Pfizers efforts to secure exclusive rights to emerging GLP-1 modalities, including an oral GLP-1 candidate in early-stage development with Shanghai Fosuns YaoPharma, reflected a broader industry push to diversify delivery formats and expand market reach

[PMC free article: PMC2556428] [PubMed: 18760392] 68

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Normally tethered through a transmembrane domain to the ER, ER stress results in cleavage of the cytoplasmic amino terminal b-ZIP domain, enabling it to translocate to the nucleus and to activate transcription from cyclic adenosine monophosphate (AMP)responsive elements