After exposition at different times and at different doses, eryptosis was evaluated
However, it was found to selectively induce apoptosis in human lymphoma cells, Daudi, Raji and Jurkat cells, by depleting the intracellular glutathione level rather than increase it
doi: 10.1016/j.coi.2015.10.009 354 Ostrand-RosenbergSFenselauC
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2297-C DEVELOPMENT OF A NOVEL IN VITRO MITOCHONDRIAL TOXICITY TEST BASED ON ATP INHIBITION SUBSTRATE ASSAY Hyunwoo Oh 1 , Hyo Young Lee 1 , Eileen Yoon 2 , Huiyul Park 3 , Sang Bong Ahn 4 , Joo Hyun Sohn 2 and Dae Won Jun 2 , (1)Uijeongbu Eulji Medical Center, (2)Hanyang University College of Medicine, (3)Hanyang University, (4)Eulji Medical Center Background: Mitochondrial toxicity has led to the withdrawal of numerous drugs from the market, highlighting the importance of assessing mitochondrial dysfunction during drug development
