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As a word of caution, these favorable outcomes are preliminary and require confirmation

The maintenance dose can go up to 2.4 mg weekly, based on how well you respond

Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity

Weight Loss: The average percent weight loss from patients starting weight after these 17 months at the maintenance dose was: -15% weight loss from baseline body weight at 68 weeks at the 2.4mg dose -In a two year follow up study, those who continued to take semaglutide at the 2.4mg dose were able to maintain an average of 15.2% of their initial weight