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During the process of malignant transformation in normal tissues, the expression of the P-gp transporter encoded by the multidrug resistance gene 1 (MDR1) gene increases (Lu et al., 2000)

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In their retrospective matched cohort study, the authors report a significant association between semaglutide use and an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION), a potentially vision-threatening condition