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Others experience gradual benefits over several weeks of consistent use

Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)

Reproductive performance of rats supplemented with L-carnitine

While urinary excretion of VC metabolites (oxalate, threonate) maintains systemic balance, prolonged deficiency ( ShacterEet alAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

The honest summary is that no one can presently say what a "working" Dihexa timeline looks like in humans, because that timeline has never been measured.