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The iron-overloaded environment of follicular fluid could not only inhibit the expression of GPX4 and its upstream regulatory target GSH but also cause the high expression of NCOA4 in granulosa cells

Staley K, Ahmadi KR, Carter K, Cowan K, Seage H, Visser P, et al

Lead, cadmium, arsenic, and mercury progressively accumulate in the organism and contribute to the degradation of this protective barrier, making their removal an important consideration in comprehensive concussion rehabilitation

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