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doi: 10.1186/s13722-025-00618-2 153 VolkowN

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Combining metabolism, electrophysiology, and blood flow, our model required the following data: molar concentrations of molecules (metabolites, proteins, and ions), enzyme and transporter kinetic parameters, electrophysiology and blood flow dynamics parameters, rate equations for all processes, mechanisms of reactions, and data on their inhibitors and activators (with corresponding mechanisms of action, existing pathway models, and their combinations)

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FDA =Food and Drug Administration