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However, in rare casessuch as patients with kidney disease or specific hereditary disorders related to vitamin B12 metabolismhigh doses or inappropriate use could potentially cause complications

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Disulfiram, a longstanding medication approved to treat AUD works by causing an irreversible pharmacological blockade of the enzymatic process that metabolizes acetaldehyde (produced by the partial oxidation of alcohol via the alcohol dehydrogenase) to acetate [33]

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