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8 One study compared the effectiveness of sublingual B12 with B12 injections for raising levels in patients with vitamin B12 deficiency

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MMADHC then transports cobalamin (II) bound to MMACHC to the MeSe enzyme in the cytosol and MMUT in the mitochondria

Because of this, I recommend any patient who is symptomatic and has suboptimal levels of vitamin B12 (as defined above) consider a trial of sublingual B12

individual risk rises with increasing dose and duration, underscoring the importance of using the minimum effective dose and conducting periodic clinical reassessment