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Dosing runs daily or weekly depending on the compound, with weekly cadence common in this part of the class

Citation18 Senolytics reduce SASP not only by eliminating the senescent cells that produce high ROS but also by disrupting pro-survival signaling pathways that sustain SASP activity

Observations indicating a parallel, opposing influence of Nrf2 on the transcriptional upregulation of pro-inflammatory genes suggest that targeted pharmacological activation of the Nrf2 pathway could help in the controlled reduction of oxidative stress (Kobayashi et al

10.1021/jp504076a 24 AstonF