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Cardiovascular mortality was reported in 9 of the 11 studies

Houser 2000)

The lactate shuttle during exercise and recovery

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As discussed above, endogenous GLP-1 is rapidly degraded by DPP-4, whereby it loses its insulinotropic activity, and preventing this degradation results in increased intact GLP-1 levels, improved pancreatic islet responses (enhanced insulin and suppressed glucagon levels) and beneficial effects on glucose homeostasis