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If you hit week 16 at 1.7 mg with less than 5% loss and no significant cardiometabolic benefit, a frank conversation with your prescriber about alternative agents (tirzepatide, for example) is appropriate

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It is also essential for folate and related one-carbon metabolism, where FAD is required as a cofactor for methylenetetrahydrofolate reductase (MTHFR), a key folate-metabolizing enzyme

Why Its Important on GLP-1 : Reduced appetite and lower food intake can lead to decreased calcium consumption