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Even if you were to inject the small amount of air seen in a typical champagne bubble, the volume of air is far too low to cause any physiological harm to the tissue

The National Institutes of Health (NIH) Consensus Conference listed the histologic criteria as follows: architectural disorder with asymmetry, subepidermal (concentric eosinophilic and/or lamellar) fibroplasia, and lentiginous melanocytic hyperplasia with spindle or epithelioid melanocytes aggregating in nests of variable size and forming bridges between adjacent rete ridges