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However, the understanding of the stereochemistry of the MSA-DH reaction is crucial for the elucidation of the overall carnitine degradation pathway: L-malate might be directly channeled into the tricarboxylic acid cycle whereas D-malate would require a specific oxidation step that potentially yields the central metabolite oxaloacetate or pyruvate

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Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP (2012)

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