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The SURMOUNT-1 trial found that participants on tirzepatide 15mg achieved an average weight loss of 20.9% of body weight, while the STEP 1 trial found semaglutide 2.4mg produced an average of 14.9%

Cagrilintide activates amylin receptor complexes, whereas peptides such as semaglutide primarily target the GLP-1 receptor within incretin signaling pathways

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Hydration and general wellness support may also be recommended before treatment depending on individual care planning.