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We confirm that co-treatment with 5FU and mitochondrial inhibitors, particularly CI inhibitors IACS-010759 (a specific CI inhibitor under clinical evaluation 51 ) and metformin hydrochloride (a treatment for diabetes that inhibits CI 52 ), increases growth arrest and death in CRC cells (Fig

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Novo last year paid $2 billion for the rights to a Chinese drugmaker's experimental medicine, which works in the same way as Lilly's upcoming treatment

A double-blind randomized study