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10.1007/s00125-016-3874-y 40 FlintA.KapitzaC.HindsbergerC.ZdravkovicM

Some patients report improved mood stability on tirzepatide, likely because GIP signaling affects reward and motivation differently than GLP-1 alone

In vivo, Ex-4 has been demonstrated to inhibit prostate cancer cell growth by activating GLP-1R, reducing s-phase kinase-associated protein-2 (SKP2) gene expression, subsequently increasing p27Kip1 (p27) protein levels, and inducing tumor cell cycle arrest [67]