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This mechanism of action is particularly beneficial for maintaining physiological balance, especially during the winter season when antioxidant requirements are increased

The NMNAT1 and NMNAT3 transgenic mouse strains used here were as previously described (Yahata et al, 2009), and the colony was maintained through breeding heterozygous males with wild-type females, with a subsequent Mendelian ratio of offspring to be used for experiments of 50% heterozygous transgenics, and 50% wild-type littermate controls

63 The balance of DNA methylation- demethylation dynamics is maintained by DNMTs and TETs