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In addition to its central function as an intracellular antioxidant, it serves as a significant cofactor for several antioxidant enzymesincluding glutathione peroxidase (GPx) and glutathione S-transferases (GSTs)that neutralize reactive oxygen species (ROS) and other electrophilic compounds (14)

In aqueous solution at physiological pH, the complex is the dominant species in the presence of any nontrivial copper, but in copper-free conditions the apo-peptide form predominates

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