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The answer depends on your dose escalation schedule, but the Phase 2 data provides a reliable roadmap

L.MllerM.NelsonA.BerryA

doi:10.2337/dc24-1678 Opens in a new tab Managing Weight with Wegovy | Wegovy (semaglutide) Injection 2.4 mg

GLP-1 Drugs and Melatonin: Why There's No CYP450 Drug Interaction (and What the Real Risk Is) If you search for a drug interaction between melatonin and semaglutide, you will likely find a reassuring answer: no interaction detected