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All their patients with pneumonia caused by SARS-CoV-2 who develop SRF display hyper-inflammatory responses with two features: over-production of pro-inflammatory cytokines by monocytes and dysregulation of lymphocytes characterized by CD4 lymphopenia and subsequently B cell lymphopenia ( However, inhibiting TNF has a direct effect in reducing the level of IL-6 and IL-1 along with adhesion molecules and vascular endothelial growth factor (VEGF) in RA patients (4044)