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Most effects will fade over time, and any side effects typically resolve on their own

It does not disrupt the interaction between dimers in the glutaminase tetramer but binds to the hydrophobic pocket between the monomer-monomer interface of the GAC, located at the junction where the N-terminal and C-terminal of the enzyme meet the catalytic domain, thereby preventing the GAC from activating conformational changes (Wilson et al., 2013

However, its clinical application must be approached with a critical and nuanced understanding of the current evidence gap

In this way AngIV may act in combination with AT 1 receptor blockade to protect DA neurons

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