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IGF and proinsulin share homology such that both of their respective receptors, IGFR and the insulin receptor (IR), will bind to the alternate growth factors albeit with reduced affinity ( The vast majority of GH actions are mediated through the JAK-STAT signaling events which has multiple complex roles, such as regulating cell proliferation and oocyte maturation (Figure 1) (115, 116) and significant downstream crosstalk with the other pathways (117)

Clinical Implications Based on Extraction Ratio 15 High-Extraction Drugs (High E): These drugs, by definition, have a low oral bioavailability (F is low)

This poor oral bioavailability explains why clinical trials used subcutaneous injection