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In follicular macrophages from RA, upregulation of the BCAA transporter SLC7A5 is closely associated with activation of the mTORC1 signaling pathway, which in turn promotes M1 macrophage polarization and arthritic tissue damage (87)

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A tendency to develop celiac disease is genetic (inherited)

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Similar changes in reduced activity of GST and GR were reported in susceptible mutants infected with TuMV (Otulak-Kozie et al., 2022b, 2023) after 7dpi which was associated with increased activity of GPXL in rbohD mutants (Otulak-Kozie et al., 2023)