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GLP-1s and Existing Underactive Thyroid (Hypothyroidism) While the cancer risk is the most talked-about "thyroid issue," a more common practical concern involves how GLP-1s affect those already taking medication for an underactive thyroid, such as levothyroxine

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For the latter, the reninangiotensinaldosterone system inhibitors (RAS) blockers are used, given their renoprotective efficacy beyond blood pressure lowering per se

Lim WS, Ng DL, Kor SB, Wong HK, Tengku-Muhammad TS, Choo QC, Chew CH (2013) Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPAR) in human hepatocarcinoma HepG2 cells by activation of NF-B pathway