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3 It is a potent free radical scavenger that also activates several cell signaling pathways associated with the production of new mitochondria and the regulation of cellular energy metabolism.* 3,4 PQQ has been shown to counteract toxin- and free radical-induced neurodegeneration and to enhance the synthesis of nerve growth factor.* 3,5 These biological properties are especially important for cells with high energy demands, such as those found in the heart and brain.* 3,5,6 Supplementing the diet with PQQ may therefore support heart health and promote normal cognitive function as we age.* 7-9 To illustrate, in a randomized, double-blind, placebo-controlled clinical study, healthy older individuals (average age 70 y) received 20 mg PQQ or placebo for 12 weeks