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Eur J Pediatr 1988;148(3):193-197

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In rodents, central GLP-1 receptor activation stimulates sympathetic outflow to adipose tissue, induces thermogenic gene programs, and promotes browning of white adipose depots ( In humans, however, BAT mass is limited, heterogeneous, and reduced in obesity, and even maximal activation contributes only modestly to total energy expenditure (31)