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doi:10.5009/gnl18490 46

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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity), a phase 3 study involving 17,604 adults with overweight or obesity and pre-existing CVD but no diabetes, revealed that once-weekly subcutaneous semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% compared with placebo over a mean follow-up of 39.8 months, including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke [48]

Buhner et al., 2022), and upregulate brain-derived neurotrophic factor (BDNF) mRNA and protein, leading to improved behavioral and cognitive outcomes in SZ animal models (Phensy et al., 2017

Supplementation may support the repair processes that peptides are stimulating at the cellular level