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85 High-quality clinical trials are sorely needed to truly evaluate BPC-157s benefits and risks in people

Reduction of disulfinide protein can be done by thioredoxin or thioredoxin reductase

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However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

Zagon IS, Mclaughlin PJ (2017) Endogenous opioids in the etiology and treatment of multiple sclerosis