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As a class, the top five GLP-1s are already bigger than oncology heavyweights Keytruda and Darzalex, the second-largest oncology drug

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55 Although adiponectin does not seem to cross the blood-brain barrier, 56,57 the ARC 58 and the area postrema 59 respond to adiponectin, suggesting that these cells could be involved in relaying the signal to other brain regions

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