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This validation approach was particularly appropriate given that the BLSA cohort represents approximately 25% of the size of SNAC-K cohort and that not all biomarkers were measured, making full model retraining unfeasible but still allowing for a meaningful assessment of generalizability through external prediction

Remember the adage "start low and go slow," says Dr, Peter Vash, M.D., a Los Angeles-based internist and endocrinologist specializing in obesity medicine

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