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If targets are not achieved, additional RAI should be added at one and then two other mealtimes (basal-bolus) as required, with titration as for the initial RAI [2, 3, 18]

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Ipamorelin would be likely ineffective in the treatment of growth hormone deficiency, especially for patients with primary hypopituitarism who have damaged the pituitary gland and their natural production of hGH is completely shut down