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CAS and HAM conceived the experiments, and CAS wrote the manuscript

Yipkin Calhan, Weile Liu, Amani Akkoub, Karan Malik, Kaleigh I

Most of the study participants were well past the window where we often start therapy

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Yes chronic alcohol use (three or more drinks per week) creates baseline suppression of GHRH tone and reduces hepatic IGF-1 production, lowering peptide therapy effectiveness by 3060% over 90 days compared to non-drinkers