doi: 10.3389/fimmu.2024.1465191 197 RietTChmielewskiM
Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects
Evidence: What We Can and Cant Say For most wellness goals (anti-aging, fat loss, muscle gain), rigorous human evidence is limited and outcomes are hard to separate from sleep, nutrition, training, and placebo effects
Furthermore, it can promote plaque buildup which can damage and narrow arteries and increase blood pressure, leading to increased risks for developing cardiovascular diseases such as atherosclerosis and thrombosis
Earlier intervention, when follicles are miniaturized but not gone, is where the evidence is most plausible
