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To investigate the influence of a Western diet, 7- to 10-week-old WT and Gpx4 +/IEC mice were fed a Western diet (ssniff, TD88137) with or without 10% fish oil (ssniff supplementation, see Table S2) and compared to mice receiving a low-fat diet (ssniff, CD88137) for 3 months ad libitum with or without -tocopherol supplementation (0.4 mg/ml, Sigma) in drinking water ad libitum

Dietary Fiber to Boost GLP-1 Dietary fiber is a type of carbohydrate that the body cannot break down during digestion

Hepcidin detection ELISA kit (#E4692-100) was obtained from Biovision (California, USA)

Future designs could further investigate the ligand-directed targeting strategies to enhance BBB penetration 29

At 10 M, growth was inhibited by 14.8%, and at 10 M by 81.5%