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For tesamorelin, the visceral-fat trials also reported improvements in lipid parameters lower triglycerides and an improved total-to-HDL cholesterol ratio alongside the VAT reduction

A similar rationale underpins regimens for Friedreichs ataxia, where riboflavin plus antioxidants (CoQ10, -lipoic acid) counter mitochondrial ironsulfur-cluster loss and free-radical injury, offering symptom relief beyond monotherapy (79, 80)

doi: 10.1042/bj1800327

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