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Abbreviations 3D: Three-dimensional DARPin: Designed ankyrin repeat protein ECD: Extracellular domain GLP-1: Glucagon like peptide-1 GR: Gyration radius HSA: Human serum albumin MD: Molecular dynamics RMSD: Root mean square deviation RMSF: Root mean square fluctuation SASA: Solvent-accessible surface area T2DM: Type 2 diabetes mellitus References Piero, M., Nzaro, G

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169 Therefore, the investigators have suggested switching to a non-oral contraceptive option or adding a barrier method of contraception for 4 weeks after tirzepatide administration is initiated or if the dose is substantially increased

The underlying reasons may involve complex interactions and alterations in various cell death pathways