Originally designed to manage type 2 diabetes, GLP-1 receptor agonists mimic the effects of glucagon-like peptide-1 , a hormone that regulates appetite, blood sugar, and fat metabolism
According to an IQVIA article, by mid-2025, GLP-1s made up more than half of all diabetes prescriptions and 23% of all first-line starts (up from 3% in 2021), displacing metformin and other cheaper generics that historically start the diabetes treatment journey
This combination can increase the risk of falls, disability, and metabolic disease even in those with high body weight
Last Published 07.01.2026 Effective Date: 07.01.2026 This policy addresses transcatheter heart valve (aortic, mitral, pulmonary, tricuspid) procedures
Nat Rev Endocrinol 14:390403 Ansari MN, Rehman NU, Karim A, Soliman GA, Ganaie MA, Raish M, Hamad AM (2021) Role of oxidative stress and inflammatory cytokines (Tnf- and il-6) in acetic acid-induced ulcerative colitis in rats: ameliorated by otostegia fruticosa