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There is an increased risk of diabetic retinopathy for those that have diabetes and have a history of diabetic retinopathy and a rapid reduction in the A1c

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Naltrexone-Bupropion (Contrave) Contrave combines naltrexone, used to treat addiction, with bupropion, an antidepressant

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The FDA does not flag a specific contraindication, but healthcare providers recommend heightened monitoring when combining these therapies

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The agency is not aware of any basis for compounding using the salt forms that would meet the FD&C requirements for types of active ingredients that can be compounded

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