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A : Compounded semaglutide is a medication tailored for individual needs but is not FDA-approved

Because GLP-2 acts through subepithelial myofibroblasts, which are the same cell population implicated in intestinal fibrogenesis, the risk-benefit profile of GLP-2 agonism may differ substantially between mucosal UC, inflammatory ileal CD, and stricturing or penetrating CD phenotypes, and this phenotypic stratification should be a required feature of future trial design

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Compounded semaglutide from PlexusDx's licensed 503A pharmacies contains the same active ingredient as brand Wegovy but may use different stabilizers or excipients that affect digestion timing slightly

One conceived in the wake of recombinant DNA technology in the 70s, shaped by early anglerfish experiments in the 80s, and given further structure by elegant biochemical studies of GPCR signaling in the 90s