De Bernardis et al., 2018)
A simplistic underlying hypothesis is that mtDNA polymorphisms might impact energy metabolism during both a resting state, by decreasing the ability to preserve transmembrane ion gradients and hence predisposing to a hyperexcitability state, and during stress circumstances by failing to mount a greater energy supply for increased demand
If the Nobel committee had recognized the tripeptide's significance earlier, research funding would have shifted toward intracellular antioxidants in the 1940s rather than the 1970s, potentially identifying the glutathione-peroxidase system 20 years sooner
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